Human Hematopoietic Genetics

Preclinical research sets the stage for a universal gene therapy for DBA, regardless of the mutation. The key: GATA1.

A genetic variant with Indigenous American ancestral origins may explain why more Hispanic/Latino children are diagnosed with acute lymphoblastic leukemia.

Researchers have developed a way to monitor changes in human blood cells in real time, raising hopes it might one day predict disease risk before symptoms arise.

By editing individual DNA “letters” in blood cells, scientists better understand the molecular underpinnings of some genetic diseases.

A study of a rare bone marrow disorder reveals that even healthy stem cells are vulnerable to iron-induced cell death.

The genetic changes found in Lynn’s type of leukemia have helped researchers determine what the genes controlled by MECOM do and how those genes affect stem cell function.

A focus on understanding the root causes of childhood cancers more deeply would have far-reaching implications.

Could clonal hematopoiesis explain the reports of blood malignancies in patients undergoing sickle cell gene therapy?

A new technique called cell barcoding is giving researchers “a view of cancer that we never had before,” says Dr. Sankaran.

The lack of a cure or sustainable long-term solution for those with Diamond-Blackfan anemia, like Lindsay, inspired the Sankaran Lab to experiment with potential treatments.

When Meredith's headaches turn out to be caused by a rare blood cancer, the Sankaran Lab sets out to untangle the complicated genetics of myeloproliferative neoplasms.

A recent Sankaran Lab study, which reveals how the fetal to adult hemoglobin switch is regulated, may open new possibilities for sickle cell patients.