Human Hematopoietic Genetics
Our goal is to understand how genetic variation alters human blood and immune cell production, or hematopoiesis, in health and disease.
Stories from the Lab
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Ancient DNA reveals origin of racial/ethnic disparity in a childhood cancer
A genetic variant with Indigenous American ancestral origins may explain why more Hispanic/Latino children are diagnosed with acute lymphoblastic leukemia.
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STAT: New tool for tracing blood cells’ ancestry might one day help predict disease risk
Researchers have developed a way to monitor changes in human blood cells in real time, raising hopes it might one day predict disease risk before symptoms arise.
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Researchers use base editing to probe blood cell biology
By editing individual DNA “letters” in blood cells, scientists better understand the molecular underpinnings of some genetic diseases.
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Blood stem cells are susceptible to ferroptosis, a type of cell death
A study of a rare bone marrow disorder reveals that even healthy stem cells are vulnerable to iron-induced cell death.
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How a leukemia hijacks the genes needed by blood stem cells
The genetic changes found in Lynn’s type of leukemia have helped researchers determine what the genes controlled by MECOM do and how those genes affect stem cell function.
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Boston Globe Op-Ed: Can we prevent childhood cancer?
A focus on understanding the root causes of childhood cancers more deeply would have far-reaching implications.
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Sickle cell disease, gene therapy, and blood cancers: Mysteries remain
Could clonal hematopoiesis explain the reports of blood malignancies in patients undergoing sickle cell gene therapy?
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New York Times: Stamping barcodes on cells to solve medical mysteries
A new technique called cell barcoding is giving researchers “a view of cancer that we never had before,” says Dr. Sankaran.
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Fast tracking a novel DBA gene therapy
The lack of a cure or sustainable long-term solution for those with Diamond-Blackfan anemia, like Lindsay, inspired the Sankaran Lab to experiment with potential treatments.
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Probing a blood cancer’s genetic origins
When Meredith's headaches turn out to be caused by a rare blood cancer, the Sankaran Lab sets out to untangle the complicated genetics of myeloproliferative neoplasms.
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Decoding sickle cell disease
A recent Sankaran Lab study, which reveals how the fetal to adult hemoglobin switch is regulated, may open new possibilities for sickle cell patients.