Sankaran Laboratory

The Sankaran Lab utilizes human genetics to refine our understanding of hematopoiesis and how this process goes awry in human disease. We are particularly interested in gaining molecular insight into how hematopoietic stem and progenitor cells are able to produce red blood cells and other blood cell lineages normally and how this process is perturbed in disease, how the hemoglobin genes (including fetal hemoglobin) are regulated, and how hematopoiesis varies in humans. We are also interested in identifying opportunities to use the insight we gain from our studies to develop improved therapies for a variety of blood disorders, including sickle cell disease, thalassemia, Diamond-Blackfan anemia, aplastic anemia, myelodysplastic syndrome, and childhood leukemia. We utilize modern human genetic studies, including exome and genome sequencing, as well as functional studies of human hematopoiesis and hemoglobin gene regulation in vitro and in vivo.