Sankaran Laboratory

Blood cell production or hematopoiesis represents an important paradigm for cellular differentiation. Our laboratory is refining our understanding of hematopoiesis using human genetics and functional studies in human cells.
Our studies utilize rare and common human genetic variation to improve our understanding of red blood cell production (erythropoiesis) and globin gene regulation with application to numerous blood diseases including sickle cell anemia, thalassemia, Diamond-Blackfan anemia, and childhood leukemia.